Hpa majaw Mulberry Leaf Extract shingra tara a hpaji ninghkring wa Glucose Metabolism hpe hkan sa ai kun?

1. Botanical Background & Htunghking jai lang ai lam

Mulberry hpun lakung (Morus alba L.) hta lawm ai:

1-Deoxynojirimycin (DNJ)(0.1-0.3%) - Myit rawt ai -glucosidase hpe pat shingdang ai jak

Flavonoids(ga san san ai, isoquercrin)

Polyphens masha ni(chlorogenic acid, rutin)

Labau hta ka da ai:

Materia Medica a shingjawng ai lam gaw shi a anti-}}diabetic atsam marai ni hpe ka da ai

Htunghking Japan ni a "diabetes-prevention tsa" ngu ai.

2. Madung Karum shingtau lam & Mechanism ni

2.1 Glucose hpe hkrang shapraw ai lam

2.2 Bioactive & Targets

3. Quality Standards

3.1 Authentication

Microscopy: Hkrang nsam n kaja ai n{0}}glandular kara ni hpe n-gun ja ai hku mu lu ai

TLC a lata masat: Ra ai shara 5 ra ai

HPLC hpe shadawn shadang masat ai: 0.1% DNJ (Pharmacopoeia madang) hta grau kaba ai (sh) maren sha re.

3.2 Na a hkrang shapraw ai lam ni

Miwa Pharmacopoeia: 1.5% hta grau kaba ai (sh) maren sha re ai.5%

Japan Mungdan: DNJ 0.15% hta grau kaba ai (sh) maren sha re.

EU tara upadi: Tsi mawan ni hpe sat kau ai lam<0.01ppm

4. Tsi gawk na sakse

4.1 Ana zinli hpe hparan ai lam

Type II DM: 1200mg/day gaw HbA1c hpe 0.8-1.2% shayawm ya ai.

Prediabetes: NNT=8 gaw, hka n-gun n-gun n-gun n-gun n-gun n-rawng hkra makawp maga na matu

4.2 Metabolic akyu ara ni

Lipid tara masa: 15-20% triglyceride hpe shayawm ai

Weight hparan hpareng ai lam: 2-3cm shingdu de na grup yin (bat 12)

5. jai lang mai ai lam

5.1 Ladat hpe jai lang ai

Npawt nhpang: 300mg (30min pre{2}}meal)

grai ahkyak ai; grai n-gun dat ai: 600mg + chromium combo .

5.2 Synergistic hpawng de ai lam

Gymnema mare masha ni: Insulin hpe n-gun ja shangun ai

Alpha- lipic acid: Peripheral glucose hpe jai lang ai lam hpe grau kaja hkra galaw na

Probiotics: N-gup n-gu n-gun- Pancreas axis

6. Hkamja lam hpe myit yu ai lam

Hypoglycemia ana byin wa na masa: Antidiabetics hte yu reng ra ai

Surgical machyi masha ni: Bat 1 tup pre-op .

GI hkam sha lam: Dose n law ai kaw nna hpang u

7. Product lata ai lam matsun

Premium arung arai ni a hkrang:

Label galaw da ai DNJ ni

Low- aten kadun hpe shaw la ai

N-gun ja ai magri chyam dinglik ai lam ni

Common Lam:

Lawu tsang{0}}}DNJ amyu ni hpe galai shai u

Synthetic DNJ hpe n hkru n kaja ai hku galaw ai

8. Hpaji sawk sagawn hpung ni

Gut microbiota: Akkermansia law jat wa ai

NAFLD hpe gram lajang ai lam: Hepatic stellate cell ni hpe pat shingdang ai

Hkamja lam hpe n-gun jaw ai tsi ni: DNJ galaw ai lam hpe galu shangun ai

Hpaji masa hte seng ai lam

Mulberry hpun lakung kaw na pru wa ai gaw:
1️⃣ Multi-target tara ni(gut+liver+peripheral tissues)
2️⃣ shingra tara shimlam(2000 ning na jai lang ai labau)
3️⃣ Hkum tsup ai metabolic akyu ni(glucose+lipid+weight)